Amilin 10mg Tablet

✔️ Uses of Amilin 10mg Tablet

It is used to treat:

• Depression
• Neuropathic pain
• Chronic headaches and migraine

✔️ How does Amilin 10mg Tablet work?

Amitone 10 MG Tablet works by increasing the levels of chemical substances in your brain (norepinephrine and serotonin). Thus, it helps to improve your mood. It also prevents the pain signals from being sent from nerves to the brain, thus providing relief from nerve pain.

✔️ Side Effects of Amilin 10mg Tablet

• Drowsiness or sleepiness
• Shakiness
• Dizziness
• Dizziness when getting up suddenly from a sitting position
• Headache
• Dry mouth
• Constipation
• Excessive sweating
• Weight gain
• Slow or slurred speech
• Nasal congestion
• Confusion
• Decrease in sexual drive
• Increased thirst
• Difficulty in passing urine

✔️ Quick Suggestions:

• Avoid consuming alcohol when taking Amitriptyline as it may cause excessive sleepiness.
• Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
• It may cause a sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
• It may take 4 to 6 weeks for Amitriptyline to start working. Keep taking it as prescribed.
• It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
• Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
• Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.

✔️ Indication of Amilin 10mg Tablet

Amilin 10 is known as a tricyclic antidepressant. Amilin 10 is a medication used to treat depression. At different doses, it is also used to treat and prevent chronic nerve-related (neuropathic) pain, migraine, tension-type headache, and nighttime bedwetting (nocturnal enuresis) in older children (6 years and up).

✔️ Pharmacology

The mechanism of action of this drug is not fully understood. Amitriptyline is thought to inhibit the membrane pump mechanism, which allows transmitter amines such as norepinephrine and serotonin to re-enter the brain, thereby increasing their concentration in synaptic clefts. These amines are essential for mood regulation. One of the oldest theories about depression is that depression is caused by a lack of serotonin (5-HT) and/or norepinephrine (NE) neurotransmission in the brain.

✔️ Dosage & Administration of Amilin 10mg Tablet

• Depression: 75 mg (Elderly and Adolescents 30-75 mg) daily in divided doses or as a single dose at bedtime, gradually increased to 150-200 mg as needed; Children under the age of 16 are not recommended for depression.
• Nocturnal enuresis: 10-20 mg for children aged 7 to 10, 25-50 mg for children aged 11 to 16, with a maximum dose of 100 mg. Treatment period (including gradual withdrawal) 3 months-full physical examination before the next course
• Migraine prophylaxis: 100 mg daily.
• 10-25 mg three times per day for tension headaches.

✔️ Interaction

Alcohol and opioid analgesics have a stronger sedative impact when combined with TCA. TCA raises the risk of ventricular arrhythmias when used with Moxifloxacin or Terfenadine. Amitriptyline metabolism is inhibited by Disulfiram and Cimetidine. TCA increases the risk of postural hypotension when used with diuretics.

✔️ Contraindications

Myocardial infarction, arrhythmias, especially heart block of any degree, mania, and severe liver illness are all contraindications to taking amitriptyline. Sedation might impair one's ability to drive or operate machines at first.

✔️ Pregnancy & Lactation

Pregnancy Classification C. It has been proven that amitriptyline crosses the placenta. During pregnancy, amitriptyline should only be taken if the possible benefit to the mother outweighs the danger to the fetus. Amitriptyline is passed through the breast milk. Because Amitriptyline has the potential to produce significant adverse effects in nursing infants, a choice should be taken whether to stop breastfeeding or stop taking the medicine, taking into consideration the drug's value to the mother.

✔️ Precaution & Warnings

• In individuals with a history of epilepsy, glaucoma, urinary retention, heart illness, diabetes, pregnancy, hepatic impairment, thyroid disease, elevated intra-ocular pressure, or psychoses, it should be taken with caution (may aggravate mania).
• Amilin 10 may take 4 to 6 weeks to begin working. Continue to take it as directed.
• It may cause drowsiness. Take it before bedtime and avoid driving or doing anything that requires concentration until you know how it affects you.
• When taking Amilin 10, avoid drinking alcohol as it may cause excessive sleepiness.
• Keep an eye on your weight during treatment because this medication can cause weight gain and an increase in appetite.
• It may cause a sharp drop in blood pressure. If you've been sitting or lying down, get up slowly.
• Consult your doctor if you experience sudden mood swings or suicidal thoughts.

✔️ Storage Conditions

Store in a cool and dry place, below 30°C. Protect from light and moisture.